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Eliquis (apixaban) Mechanism of Action

An oral, direct and highly selective factor Xa inhibitor1

ELIQUIS inhibits free and clot-bound factor Xa, and prothrombinase activity.

ELIQUIS has no direct effects on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting factor Xa, ELIQUIS prevents thrombin generation and thrombus development.1

  • Factor Xa is the primary site of amplification in the coagulation cascade2
  • ELIQUIS binds reversibly to Factor Xa1
  • One factor Xa molecule leads to the formation of ~1,000 thrombin molecules2

Adapted from Eriksson et al. 2011.3

Purple information icon ELIQUIS (apixaban) SmPC

Please click here to access the ELIQUIS SmPC.

Purple information icon ELIQUIS (apixaban) Patient Information Leaflet

Please click here to access the ELIQUIS Patient Information Leaflet.

DVT = Deep Vein Thrombosis   
NVAF = Non-Valvular Atrial Fibrillation   
PE = Pulmonary Embolism   
TF = Tissue Factor


  1. ELIQUIS® (apixaban) Summary of Product Characteristics.
  2. Turpie AGG. Arterioscler Thromb Vasc Biol 2007; 27: 1238–1247.
  3. Eriksson BI et al. Annu Rev Med 2011; 62: 41–57.