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in the UK.
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ELIQUIS® (apixaban) is indicated for prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF), with one or more risk factors, such as prior stroke or transient ischaemic attack (TIA), age ≥75 years, hypertension, diabetes mellitus, symptomatic heart failure (NYHA Class ≥II); treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults; and, prevention of venous thromboembolic events (VTE) in patients who have undergone elective hip or knee replacement surgery.
AMPLIFY-EXT Clinical Trial
In AMPLIFY-EXT, in patients receiving extended treatment for prevention of recurrent DVT and PE, ELIQUIS® 2.5 mg BD demonstrated superior efficacy, with no statistically significant increase in the rates of both major and major / CRNM bleeding vs. placebo1,2*
Discover the data supporting ELIQUIS in the prevention of recurrent VTE
* The AMPLIFY-EXT clinical trial was a 12-month, randomised, double-blind placebo-controlled trial in 2,482 patients with VTE who had been treated for 6–12 months with standard anticoagulation therapy or had completed treatment with ELIQUIS or enoxaparin / warfarin as participants in the AMPLIFY trial and for whom there was clinical uncertainty about the benefit of continuing treatment.1
† The primary efficacy endpoint was the composite of symptomatic recurrent VTE or death from any cause.1 Recurrent VTE included fatal or non-fatal PE and DVT.1
‡ The primary safety endpoint was major bleeding.1 For patients who had more than one event, only the first was counted.1
§ The secondary safety endpoint was the incidence of major or CRNM bleeding events.1 For patients who had more than one event, only the first was counted.1
ARR = Absolute Risk Reduction BD = Twice Daily CI = Confidence Interval
DVT = Deep Vein Thrombosis N = Total number of patients in either the ELIQUIS group or the placebo group n = Number of patients with event PE = Pulmonary Embolism RR = Relative Risk
SmPC = Summary of Product Characteristics
VTE = Venous Thromboembolism