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ELIQUIS® (apixaban) is indicated for prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF), with one or more risk factors, such as prior stroke or transient ischaemic attack (TIA), age ≥75 years, hypertension, diabetes mellitus, symptomatic heart failure (NYHA Class ≥II); treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults; and, prevention of venous thromboembolic events (VTE) in patients who have undergone elective hip or knee replacement surgery.
ARISTOTLE Clinical Trial
ELIQUIS® offers superior reductions in the rates of stroke / systemic embolism AND major bleeding vs. warfarin, plus a significant reduction in all-cause mortality1
In patients with NVAF, ELIQUIS demonstrated:1
Discover the data supporting ELIQUIS for the prevention of stroke and systemic embolism in patients with NVAF from the ARISTOTLE study
* The ARISTOTLE clinical trial was a randomised, double-blind, double-dummy, non-inferiority trial in 18,201 patients with NVAF and at least one other risk factor for stroke. Stroke / systemic embolism, including haemorrhagic, ischaemic or undetermined stroke, was the primary efficacy endpoint, major bleeding according to ISTH criteria was the primary safety outcome and all-cause mortality was a key secondary endpoint.1 Pre-specified hierarchical sequential testing was performed first on stroke / systemic embolism (primary efficacy endpoint) for non-inferiority, then for superiority, then on major bleeding, and finally, on death from any cause (secondary endpoint).1 The median duration of follow-up was 1.8 years.1
ARR = Absolute Risk Reduction CI = Confidence Interval HR = Hazard Ratio
ISTH = International Society on Thrombosis and
Haemostasis N = Total number of patients in either the ELIQUIS group or the warfarin group n = Number of patients with event
NVAF = Non-Valvular Atrial Fibrillation RRR = Relative Risk Reduction