Hypersensitivity to the active substance or to any of the excipients1
Active clinically significant bleeding1
Hepatic disease associated with coagulopathy and clinically relevant bleeding risk1
Lesion or condition if considered a significant risk factor for major bleeding; this may include current or recent gastrointestinal ulceration, presence of malignant neoplasms at high risk of bleeding, recent brain or spinal injury, recent brain, spinal or ophthalmic surgery, recent intracranial haemorrhage, known or suspected oesophageal varices, arteriovenous malformations, vascular aneurysms or major intraspinal or intracerebral vascular abnormalities1
Concomitant treatment with any other anticoagulant agent e.g. unfractionated heparin (UFH), low molecular weight heparins (enoxaparin, dalteparin, etc.), heparin derivatives (fondaparinux, etc.), oral anticoagulants (warfarin, rivaroxaban, dabigatran, etc.), except under specific circumstances of switching anticoagulant therapy or when UFH is given at doses necessary to maintain an open central venous or arterial catheter1
ELIQUIS is approved for a broad range of indications1
Please click here to access the ELIQUIS Patient Information Leaflet.
UFH = Unfractionated Heparin
ELIQUIS® (apixaban) Summary of Product Characteristics.
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Date of preparation: February 2019